Nikolaos A Papanikolaou, Ph.D

I study cancer as a dynamically stabilized, systems-level disease, investigating how metabolite allocation, epigenetic regulation, network architecture, and nonlinear cell-state dynamics lock cells into malignant, drug-resistant states. Current themes: • Protein arginine/lysine methylome in cancer and differentiation • Molecular-dynamics analysis of driver mutations and inhibitor binding (e.g., c-KIT D816V) • Network-, entropy-, and chaos-theoretic analysis of interactomes and resistance • Glioblastoma: methylation of methylases as self-reinforcing epigenetic circuits • Translating systems-level modeling into precision medicine (Akesis Med; EP 1010527)